Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.61 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.61 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.61 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.61 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | F10 | P00742 | 2/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.56 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28390021 | 0.89 | MEN1 (0.71) | PPIAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4256172 | 0.88 | MEN1 (0.67) | PPIAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4874500 | 0.85 | PDK1 (0.58) | PPIAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL5104712 | 0.85 | MEN1 (0.64) | PPIAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4260471 | 0.84 | KDR (0.67) | MEN1KMT2ARAB9ANPC1BAZ1A | |
| SCHEMBL4884248 | 0.83 | PDK1 (0.56) | PPIAPDK1PDK2PDK3PDK4 | |
| SCHEMBL21497178 | 0.83 | MAOB (0.71) | MEN1KMT2ARAB9ANPC1PDK1 | |
| SCHEMBL13956782 | 0.82 | MEN1 (0.69) | MEN1KMT2ARAB9ANPC1POLB | |
| SCHEMBL2434151 | 0.81 | PPIA (0.61) | PPIAMEN1KMT2ARAB9APOLB | |
| SCHEMBL14086749 | 0.81 | PDK1 (0.53) | PPIARAB9ANPC1PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023731-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2009-01-22 | — | — | US | claimed |
| US-20090023731-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2009-01-22 | — | — | US | disclosed |
| US-20090023731-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. | 2009-01-22 | — | — | US | disclosed |
| WO-2008116145-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008116145-A2 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | ARETE THERAPEUTICS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023731-A1 | SOLUBLE EPOXIDE HYDROLASE INHIBITORS | EPHX1, EPHX2, NCEH1 | PPIA 1728/4885MEN1 4139/4885KMT2A 3308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.