Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.51 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL11005843 | 0.98 | GRM8 (0.50) | GRM8GRM4CSNK2A1SMN1; SMN2NOS1 | |
| SCHEMBL10074962 | 0.81 | GRM8 (0.51) | GRM8GRM4CSNK2A1SMN1; SMN2NOS1 | |
| SCHEMBL13095825 | 0.81 | GRM8 (0.51) | GRM8GRM4CSNK2A1SMN1; SMN2NOS1 | |
| SCHEMBL5029681 | 0.79 | GRM8 (0.47) | GRM8GRM4CSNK2A1SMN1; SMN2NOS1 | |
| SCHEMBL11037988 | 0.76 | SMN1; SMN2 (0.54) | GRM8GRM4CSNK2A1SMN1; SMN2NOS1 | |
| SCHEMBL5875737 | 0.74 | — | — | |
| SCHEMBL5875700 | 0.69 | GRM8 (0.38) | GRM8GRM4CSNK2A1NOS1ALDH1A1 | |
| SCHEMBL2896671 | 0.68 | — | — | |
| SCHEMBL5023786 | 0.68 | NPC1 (0.41) | SMN1; SMN2BLMKMT2AMAPTGAA | |
| SCHEMBL34467428 | 0.67 | CSNK2A1 (0.57) | GRM8GRM4CSNK2A1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59164785-A | — | — | None | — | — | JP | disclosed |
| US-20090281142-A1 | THIAZOLE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-12 | — | — | US | disclosed |
| EP-1921074-A1 | THIAZOLE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |
| EP-0574118-A1 | Polycyclic dyes | ZENECA LIMITED (GB) | 1993-12-15 | — | — | EP | disclosed |
| US-4560765-A | USING 183-THIAZOL-4-YL GLYOXYLIC ACID AS INTERMEDIATE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-12-24 | — | — | US | disclosed |
| JP-S59164785-A | 2-(2-AMINO-5-THIAZOLYL)-HYDROXYACETIC ACID ESTER AND ITS PREPARATION | NIPPON SYNTHETIC CHEM IND CO LTD:THE | 1984-09-17 | — | — | JP | disclosed |
| US-4440766-A | CEPHALOSPORINS; BACTERICIDES; MICROBIOCIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-04-03 | — | — | US | disclosed |
| US-4303655-A | MICROBIOCIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281142-A1 | THIAZOLE DERIVATIVE | GK, GCKR, AK2 | GRM8 565/4885GRM4 502/4885CSNK2A1 1582/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.