AK2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Cudc-101 (SCHEMBL93769)	1.00	1/20
SCHEMBL641667	1.00	1/20
SCHEMBL4740600	1.00	1/20
SCHEMBL8212688	1.00	1/20
Cudc-101 (SCHEMBL29350202)	1.00	1/20
Cudc-101 (SCHEMBL29379912)	1.00	1/20
SCHEMBL643712	0.98	1/20
SCHEMBL8213005	0.98	1/20
SCHEMBL31424948	0.98	1/20
SCHEMBL642322	0.93	1/20
SCHEMBL641997	0.89	1/20
SCHEMBL4893540	0.89	1/20
SCHEMBL8205021	0.89	1/20
SCHEMBL8209586	0.89	1/20
SCHEMBL8211976	0.89	1/20
SCHEMBL8212478	0.88	1/20
SCHEMBL8212683	0.88	1/20
SCHEMBL13882718	0.88	1/20
SCHEMBL642988	0.86	1/20
SCHEMBL8204440	0.85	1/20

Clinical trials — most relevant to AK2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Alpha Ketoglutarate Enhances Geroprotection In Surgery (AEGIS)	PHASE4	RECRUITING
Genomic Outcomes of Metformin	PHASE4	COMPLETED
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
Clinical Evaluation of the Effect of Metformin in Sepsis	PHASE3	UNKNOWN
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
The Effect of Addition of Metformin to SGLT2 In Diabetic Patients With Heart Failure With Preserved Ejection Fraction	PHASE2/PHASE3	UNKNOWN
Bempedoic Acid Therapy for Polycystic Kidney Disease	PHASE2	NOT_YET_RECRUITING
Acetylcarnitine and Insulin Sensitivity	PHASE2	COMPLETED
The Effect of Addition of Metformin In Obese Non- Diabetic Patients With Heart Failure With Preserved Ejection Fraction	PHASE2	UNKNOWN
Safety and Feasibility of Metformin for Sepsis Induced AKI	PHASE2	COMPLETED
Effects of Roflumilast on Insulin and Blood Sugar Levels in Prediabetic Overweight and Obese Individuals	PHASE1/PHASE2	COMPLETED
Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia	EARLY_PHASE1	ACTIVE_NOT_RECRUITING
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes	nan	COMPLETED
TBI Multimodal Monitoring Study	nan	UNKNOWN
Mechanistic Study of PK2 Pathway in Alleviating Perioperative Neurocognitive Disorders by Improving Neurometabolic Uncoupling	nan	NOT_YET_RECRUITING
Effect of Dietary Nitrate on Immobilization-induced Changes in Skeletal Muscle in Young Healthy Men	nan	RECRUITING
McArdle Disease Treatment by Ketogenic Diet	nan	COMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Exploring the Relationship Between Androgen Metabolism, Metabolic Disease and Skeletal Muscle Energy Balance in Men	nan	UNKNOWN
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States	nan	COMPLETED
The Effect of White Tea Consumption on Obesity	nan	COMPLETED
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2	nan	UNKNOWN
ALDH2 Single Nucleotide Polymorphisms and Prognosis of Esophageal Cancer Patients	nan	RECRUITING
Purinergic Signaling and the Postmenopausal Heart	nan	RECRUITING
Effect of Age on Glucose and Lipid Metabolism	nan	COMPLETED
Cardiac Mitochondrial Function in Explanted Human Hearts	nan	UNKNOWN
Nicotinamide Riboside and Mitochondrial Biogenesis	nan	COMPLETED
Influence of WNT4 VEZT FSHB and SIRT1 SNPs in Endometriosis: a Case Control Study of the Sardinian Population	nan	UNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a AK2 binder may also engage these)

Protein	Name	Similarity
B4QBH8	—	1.000	B4QBH8 →
P29410	—	1.000	P29410 →
Q9WTP6	—	1.000	Q9WTP6 →
Q5REI7	—	1.000	Q5REI7 →
P08166	—	0.998	P08166 →
B3NQ53	—	0.998	B3NQ53 →
Q9U915	—	0.998	Q9U915 →
Q290A8	—	0.998	Q290A8 →
B3MCQ5	—	0.998	B3MCQ5 →
B4PAR6	—	0.997	B4PAR6 →
Q1L8L9	—	0.997	Q1L8L9 →
B4MQT3	—	0.996	B4MQT3 →
Q4WJ21	—	0.995	Q4WJ21 →
Q7QJX9	—	0.993	Q7QJX9 →
B4KLY1	—	0.993	B4KLY1 →
B0X5E3	—	0.993	B0X5E3 →
Q8AVD3	—	0.993	Q8AVD3 →
Q9FK35	—	0.993	Q9FK35 →
B4LP08	—	0.993	B4LP08 →
B4J672	—	0.992	B4J672 →
Q28F55	—	0.992	Q28F55 →
A5E598	—	0.991	A5E598 →
B5XCA1	—	0.991	B5XCA1 →
B4I2A8	—	0.991	B4I2A8 →
B0D360	—	0.991	B0D360 →
Q5A4Q1	—	0.991	Q5A4Q1 →
Q1HQK0	—	0.990	Q1HQK0 →
A4RD93	—	0.990	A4RD93 →
Q0C7Y1	—	0.990	Q0C7Y1 →
A6RHI1	—	0.990	A6RHI1 →