Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.74 |
| ▸ | NPC1 | O15118 | 8/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL444577 | 0.90 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL4247491 | 0.79 | NPC1 (0.51) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL4252430 | 0.79 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2TP53HPGD | |
| SCHEMBL4257390 | 0.78 | NPC1 (0.71) | RAB9ANPC1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL4255588 | 0.77 | TP53 (0.58) | RAB9ANPC1SMN1; SMN2TP53HTT | |
| SCHEMBL4250755 | 0.77 | NPC1 (0.69) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL4249444 | 0.76 | HDAC3 (0.55) | RAB9ANPC1SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL4257451 | 0.75 | NPC1 (0.70) | RAB9ANPC1SMN1; SMN2HPGDHTT | |
| SCHEMBL4247864 | 0.75 | HDAC1 (0.55) | RAB9ANPC1SMN1; SMN2HPGDHDAC1 | |
| SCHEMBL4253188 | 0.75 | KMT2A (0.53) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | RAB9A 3763/4885NPC1 1960/4885SMN1; SMN2 3469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.