Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.57 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.57 |
| ▸ | SHBG | P04278 | 3/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 1/20 | 0.57 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.57 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MGAM | O43451 | 1/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366936 | 1.00 | MEN1 (0.67) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL6130933 | 0.87 | MEN1 (0.58) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL14121739 | 0.86 | ABCB1 (0.54) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL14121738 | 0.86 | ABCB1 (0.54) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL6130951 | 0.86 | MEN1 (0.55) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL6913689 | 0.85 | MEN1 (0.72) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL23363784 | 0.84 | MEN1 (0.73) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL10971884 | 0.84 | MEN1 (0.73) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL4252612 | 0.84 | MEN1 (0.73) | MEN1KMT2ACYP19A1GPBAR1SHBG | |
| SCHEMBL6942662 | 0.84 | MEN1 (0.73) | MEN1KMT2ACYP19A1GPBAR1SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479802-B2 | Assays for screening activity of modulators of members of the hydroxy steroid (17-beta) dehydrogenase (HSD17B) family | REGENERON PHARMACEUTICALS, INC. (US) | 2022-10-25 | — | — | US | disclosed |
| EP-3610029-A1 | ASSAYS FOR SCREENING ACTIVITY OF MODULATORS OF MEMBERS OF THE HYDROXYSTEROID (17-BETA) DEHYDROGENASE (HSD17B) FAMILY | Regeneron Pharmaceuticals, Inc. (US) | 2020-02-19 | — | — | EP | disclosed |
| WO-2018190970-A1 | ASSAYS FOR SCREENING ACTIVITY OF MODULATORS OF MEMBERS OF THE HYDROXYSTEROID (17-BETA) DEHYDROGENASE (HSD17B) FAMILY | REGENERON PHARMACEUTICALS, INC. (US) | 2018-10-18 | — | — | WO | disclosed |
| US-20180291422-A1 | Assays For Screening Activity Of Modulators Of Members Of The Hydroxysteroid (17-Beta) Dehydrogenase (HSD17B) Family | REGENERON PHARMACEUTICALS, INC. | 2018-10-11 | — | — | US | disclosed |
| US-20090104122-A1 | DETECTION OF MEMBRANE ANDROGEN RECEPTOR (mAR) AGENTS | MEDEXIS S.A. (GR) | 2009-04-23 | — | — | US | disclosed |
| EP-2008099-A2 | DETECTION OF MEMBRANE ANDROGEN RECEPTOR (MAR) AGENTS | Medexis S.A. (GR) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007123682-A2 | DETECTION OF MEMBRANE ANDROGEN RECEPTOR (MAR) AGENTS | MEDEXIS S.A. (GR) | 2007-11-01 | — | — | WO | disclosed |