Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.74 |
| ▸ | CYP1A1 | P04798 | 6/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 6/20 | 0.64 |
| ▸ | MAOB | P27338 | 4/20 | 0.64 |
| ▸ | P4HB | P07237 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255384 | 1.00 | PTGS1 (0.74) | PTGS1CYP1A1CYP1B1MAOBP4HB | |
| SCHEMBL4261187 | 0.89 | HDAC1 (0.68) | PTGS1CYP1B1MAOBHDAC1KCNH2 | |
| SCHEMBL4261184 | 0.89 | HDAC1 (0.68) | PTGS1CYP1B1MAOBHDAC1KCNH2 | |
| SCHEMBL4258375 | 0.85 | MAOB (0.59) | PTGS1CYP1B1MAOBHDAC1KCNH2 | |
| SCHEMBL4258378 | 0.85 | MAOB (0.59) | PTGS1CYP1B1MAOBHDAC1KCNH2 | |
| SCHEMBL4263628 | 0.82 | HDAC1 (0.74) | CYP1B1MAOBP4HBHDAC1KCNH2 | |
| SCHEMBL4263626 | 0.82 | HDAC1 (0.74) | CYP1B1MAOBP4HBHDAC1KCNH2 | |
| SCHEMBL1064700 | 0.81 | HDAC1 (0.65) | PTGS1HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL1064701 | 0.81 | HDAC1 (0.65) | PTGS1HDAC1KCNH2HDAC2HDAC3 | |
| SCHEMBL11816722 | 0.80 | CYP1A1 (0.87) | CYP1A1CYP1B1MAOBP4HBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-01-22 | — | — | US | disclosed |
| US-7282608-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2007-10-16 | — | — | US | disclosed |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC6 | PTGS1 1914/4885CYP1A1 4448/4885CYP1B1 4130/4885 |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | HDAC1, AADAC, HDAC11 | PTGS1 1660/4885CYP1A1 1815/4885CYP1B1 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.