Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.59 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258375 | 1.00 | MAOB (0.59) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4261187 | 0.91 | HDAC1 (0.68) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4261184 | 0.91 | HDAC1 (0.68) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4259539 | 0.87 | PTGS2 (0.53) | CYP1B1HDAC1HDAC3HDAC2MAPK1 | |
| SCHEMBL4259537 | 0.87 | PTGS2 (0.53) | CYP1B1HDAC1HDAC3HDAC2MAPK1 | |
| SCHEMBL4255388 | 0.85 | PTGS1 (0.74) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4255384 | 0.85 | PTGS1 (0.74) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4263628 | 0.84 | HDAC1 (0.74) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL4263626 | 0.84 | HDAC1 (0.74) | MAOBCYP1B1HDAC1HDAC3HDAC2 | |
| SCHEMBL1064700 | 0.83 | HDAC1 (0.65) | HDAC1HDAC3HDAC2MAPK1NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2009-01-22 | — | — | US | disclosed |
| US-7282608-B2 | Inhibitors of histone deacetylase | METHYLGENE, INC. (CA) | 2007-10-16 | — | — | US | disclosed |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | METHYLGENE, INC. (CA) | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023734-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC11, HDAC6 | MAOB 2015/4885CYP1B1 4130/4885HDAC1 1/4885 |
| US-20060020131-A1 | Aryl amide, -sulfonamide, or -urea derivatives; antiproliferative, antitumor, anticarcinogenic, and/or antimetastasis agents | HDAC1, AADAC, HDAC11 | MAOB 2389/4885CYP1B1 2294/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.