Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR142 | Q7Z601 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.39 |
| ▸ | CTSC | P53634 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4399069 | 1.00 | GPR142 (0.40) | GPR142CYP3A4CTSCTDP1 | |
| SCHEMBL4251971 | 0.87 | ACACB (0.42) | GPR142CYP3A4 | |
| SCHEMBL4251176 | 0.87 | ACACB (0.42) | GPR142CYP3A4 | |
| SCHEMBL4251973 | 0.87 | ACACB (0.42) | GPR142CYP3A4 | |
| SCHEMBL4244088 | 0.84 | GPR142 (0.38) | GPR142CYP3A4 | |
| SCHEMBL4244625 | 0.84 | GPR142 (0.38) | GPR142CYP3A4 | |
| SCHEMBL4247484 | 0.83 | CYP3A4 (0.38) | GPR142CYP3A4 | |
| SCHEMBL4247488 | 0.83 | CYP3A4 (0.38) | GPR142CYP3A4 | |
| SCHEMBL4251442 | 0.82 | CYP3A4 (0.38) | GPR142CYP3A4 | |
| SCHEMBL4566333 | 0.82 | CYP3A4 (0.38) | GPR142CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081917-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | Abbott Laboratories (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008027932-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2008-03-06 | — | — | WO | disclosed |