SCHEMBL4256130

SCHEMBL4256130

FC(F)=C(F)OC=CCc1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.50
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
ARG2 P78540 1/20 0.44
TOP1 P11387 1/20 0.41
HTT P42858 1/20 0.35
IDO1 P14902 1/20 0.33
AGXT P21549 1/20 0.32
TSHR P16473 2/20 0.32
MAPK1 P28482 1/20 0.32
AOC3 Q16853 2/20 0.32
GPR52 Q9Y2T5 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
KEAP1 Q14145 1/20 0.31
CYP2C19 P33261 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14775423 0.77 MAOB (0.54) MAOBCA1CA2ARG2TOP1
SCHEMBL3359398 0.74 MAOB (0.50) MAOBCA1CA2ARG2TOP1
SCHEMBL4254918 0.74 MAOB (0.50) MAOBCA1CA2ARG2TOP1
SCHEMBL3359392 0.74 MAOB (0.50) MAOBCA1CA2ARG2TOP1
SCHEMBL217134 0.73 MAOB (0.67) MAOBCA1CA2ARG2TOP1
SCHEMBL1975588 0.73 MAOB (0.67) MAOBCA1CA2ARG2TOP1
SCHEMBL6551301 0.73 TDP1 (0.50) MAOBCA1CA2ARG2TOP1
SCHEMBL7158469 0.71 MAOB (0.56) MAOBCA1CA2ARG2TOP1
SCHEMBL11267329 0.70 MAOB (0.45) MAOBCA1CA2ARG2TOP1
SCHEMBL28485951 0.70 MAOB (0.61) MAOBCA1CA2ARG2TOP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8198375-B2 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED (US) 2012-06-12 US disclosed
US-8183325-B2 Mixture of polyoxyalkylene radical, polysiloxane radicals and perfluorocyclobutane radical; medical equipment; contact lenses BAUSCH & LOMB INCORPORATED (US) 2012-05-22 US disclosed
US-7582704-B2 Biomedical devices BAUSCH & LOMB INCORPORATED (US) 2009-09-01 US disclosed
US-20090192263-A1 TRIFLUOROVINYL AROMATIC CONTAINING POLY(ALKYL ETHER) PREPOLYMERS BAUSCH & LOMB MEXICO, S.A. DE C.V. (MX) 2009-07-30 US disclosed
US-7544751-B2 Polymerization products and biomedical devices containing same BAUSCH & LOMB INCORPORATED (US) 2009-06-09 US disclosed
US-7538160-B2 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED (US) 2009-05-26 US disclosed
US-7534836-B2 Polysiloxanes including cyclic polymers , polyethers, polyethersiloxanes with crosslinkable end groups including a dimerizable perfluorovinylphenyl group; polyperfluorocyclobutanes; contact/intraocular lenses; oxygen permeability; wettability' biocompatability; quality; prolonged eye contact BAUSCH & LOMB INCORPORATED (US) 2009-05-19 US disclosed
US-20080287626-A1 Polymerization Products and Biomedical Devices Containing Same PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.) (PL) 2008-11-20 US disclosed
US-20080234454-A1 PERFLUOROCYCLOBUTANE COPOLYMERS PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.) (PL) 2008-09-25 US disclosed
US-7425600-B2 Polymerization products and biomedical devices containing same BAUSCH & LOMB INCORPORATED (US) 2008-09-16 US disclosed
WO-2007005334-A1 PERFLUOROCYCLOBUTANE COPOLYMERS BAUSCH & LOMB INCORPORATED (US) 2007-01-11 WO disclosed
WO-2007005335-A1 BIOMEDICAL DEVICES BAUSCH & LOMB INCORPORATED (US) 2007-01-11 WO disclosed
WO-2007005356-A1 BIOMEDICAL DEVICES BAUSCH & LOMB INCORPORATED (US) 2007-01-11 WO disclosed
WO-2007005355-A1 TRIFLUOROVINYL AROMATIC CONTAINING POLY (ALKYL ETHER) PREPOLYMERS BAUSCH & LOMB INCORPORATED (US) 2007-01-11 WO disclosed
WO-2007005348-A1 POLYMERIZATION PRODUCTS AND BIOMEDICAL DEVICES CONTAINING SAME BAUSCH & LOMB INCORPORATED (US) 2007-01-11 WO disclosed
US-20070004867-A1 Perfluorocyclobutane copolymers BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed
US-20070004868-A1 Polymerization products and biomedical devices containing same BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed
US-20070004897-A1 Trifluorovinyl aromatic containing poly(alkyl ether) prepolymers BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed
US-20070004866-A1 Biomedical devices BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed
US-20070004886-A1 Biomedical devices BAUSCH & LOMB INCORPORATED 2007-01-04 US disclosed