Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 7/20 | 0.64 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2553773 | 0.83 | MAPT (0.69) | LMNAMAPTSIRT6RECQLHTR7 | |
| SCHEMBL213791 | 0.83 | LMNA (0.69) | LMNAMAPTSIRT6RECQLMAPK1 | |
| SCHEMBL213790 | 0.83 | LMNA (0.69) | LMNAMAPTSIRT6RECQLMAPK1 | |
| SCHEMBL4772717 | 0.83 | MAPT (0.72) | LMNAMAPTSIRT6RECQLHTR7 | |
| SCHEMBL16054004 | 0.83 | KMT2A (0.64) | LMNAMAPTSIRT6RECQLMAPK1 | |
| SCHEMBL4261574 | 0.82 | S1PR1 (0.50) | MAPTRECQLPOLBMAPK1ALDH1A1 | |
| SCHEMBL31306580 | 0.82 | MAPT (0.71) | LMNAMAPTSIRT6RECQLHTR7 | |
| SCHEMBL3535914 | 0.80 | LMNA (0.64) | LMNAMAPTSIRT6RECQLHTR7 | |
| SCHEMBL5058364 | 0.79 | MAPT (0.71) | LMNAMAPTSIRT6RECQLPOLB | |
| SCHEMBL3109069 | 0.79 | LMNA (1.00) | LMNAMAPTSIRT6RECQLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044938-A2 | Radioprotectors | Peter MacCallum Cancer Institute (AU) | 2009-04-08 | — | — | EP | disclosed |
| EP-0857067-A4 | RADIOPROTECTORS | PETER MACCALLUM CANCER INST (AU) | 2005-01-19 | — | — | EP | disclosed |
| US-6548505-B1 | Protecting biological materials from damage caused by radiation; side effect reduction during radiotherapy or chemotherapy; indole, benzimidazole, benzoxazole or benzothiazole compounds substituted with 4-alkylpiperazino | PETER MACCALLUM CANCER INSTITUTE (AU) | 2003-04-15 | — | — | US | disclosed |
| US-6194414-B1 | CANCER THERAPY; PREVENT RADIATION DAMAGE | THE INNER AND EASTERN HEALTH CARE NETWORK (AU) | 2001-02-27 | — | — | US | disclosed |
| EP-0857067-A1 | RADIOPROTECTORS | The Inner and Eastern Health Care Network (AU) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997004776-A1 | RADIOPROTECTORS | THE INNER AND EASTERN HEALTH CARE NETWORK (AU) | 1997-02-13 | — | — | WO | disclosed |