Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251090 | 0.92 | MAPK1 (0.46) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL445896 | 0.92 | NPC1 (0.49) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL4247842 | 0.89 | NPC1 (0.46) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL445187 | 0.83 | MAPT (0.52) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL443783 | 0.81 | NPC1 (0.52) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL4255520 | 0.78 | SMN1; SMN2 (0.51) | NPC1SMN1; SMN2RAB9AALDH1A1MAPT | |
| SCHEMBL445221 | 0.78 | MAPT (0.50) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL4250976 | 0.75 | NPC1 (0.54) | NPC1SMN1; SMN2RAB9AHDAC6HDAC2 | |
| SCHEMBL4252991 | 0.74 | KMT2A (0.56) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 | |
| SCHEMBL4248121 | 0.74 | LMNA (0.65) | NPC1SMN1; SMN2RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | NPC1 1960/4885SMN1; SMN2 3469/4885RAB9A 3763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.