SCHEMBL4257458

SCHEMBL4257458

CC(O)N(C(=O)CN)C(=O)CN

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.39
GABRP O00591 2/20 0.32
GABRD O14764 2/20 0.32
GABRA1 P14867 2/20 0.32
GABRB1 P18505 2/20 0.32
GABRG2 P18507 2/20 0.32
GABRB3 P28472 2/20 0.32
GABRA5 P31644 2/20 0.32
GABRA3 P34903 2/20 0.32
GABRA2 P47869 2/20 0.32
GABRB2 P47870 2/20 0.32
GABRA4 P48169 2/20 0.32
GABRE P78334 2/20 0.32
GABRA6 Q16445 2/20 0.32
GABRG1 Q8N1C3 2/20 0.32
GABRG3 Q99928 2/20 0.32
GABRQ Q9UN88 2/20 0.32
GABRR1 P24046 2/20 0.32
GLRA1 P23415 1/20 0.32
SLC6A9 P48067 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28568948 0.75 GABRR1 (0.39) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL15756780 0.75 GABRR1 (0.39) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL15756827 0.73 GABRR1 (0.38) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL5695058 0.70 ALDH1A1 (0.39) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL29051870 0.70 GABRR1 (0.35) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL29051871 0.70 GABRR1 (0.35) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL20508230 0.69 GAA (0.34) GAAGABRR1TP53
SCHEMBL15757064 0.69 SLC7A5 (0.43) GAAGABRR1
SCHEMBL7419483 0.69 GABRR1 (0.39) GAAGABRPGABRDGABRA1GABRB1
SCHEMBL28542660 0.69 TSHR (0.31) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090028813-A1 Methods for Treating Body Tissue PROTEIN POLYMER TECHNOLOGIES, INC. (US) 2009-01-29 US disclosed
US-20090023648-A1 Methods for Treating Body Tissue PROTEIN POLYMER TECHNOLOGIES, INC. (US) 2009-01-22 US disclosed
US-7300663-B2 Adhesion and sealing of tissue with compositions containing polyfunctional crosslinking agents and protein polymers PROTEIN POLYMER TECHNOLOGIES, INC. (US) 2007-11-27 US disclosed
EP-1656946-A1 Tissue adhesive using synthetic crosslinking PROTEIN POLYMER TECHNOLOGIES, INC. (US) 2006-05-17 EP disclosed
US-20030104589-A1 Tissue adhesive using synthetic crosslinking PROTEIN POLYMER TECHNOLOGIES 2003-06-05 US disclosed
US-6423333-B1 INJECTION TO FIX DEFECTS PROTEIN POLYMER TECHNOLOGIES, INC. 2002-07-23 US disclosed
EP-0823848-A4 TISSUE ADHESIVE USING SYNTHETIC CROSS-LINKING PROTEIN POLYMER TECH INC (US) 2000-12-20 EP disclosed
US-6033654-A Bonding together tissue with adhesive containing polyfunctional crosslinking agent and protein polymer PROTEIN POLYMER TECHNOLGIES, INC. (US) 2000-03-07 US disclosed
EP-0823848-A1 TISSUE ADHESIVE USING SYNTHETIC CROSS-LINKING PROTEIN POLYMER TECHNOLOGIES, INC. (US) 1998-02-18 EP disclosed
WO-1996034618-A1 TISSUE ADHESIVE USING SYNTHETIC CROSS-LINKING PROTEIN POLYMER TECHNOLOGIES, INC. (US) 1996-11-07 WO disclosed