Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.57 |
| ▸ | FDPS | P14324 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.54 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.54 |
| ▸ | ABAT | P80404 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | NQO2 | P16083 | 1/20 | 0.47 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
| ▸ | TUBB | P07437 | 1/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17955067 | 0.90 | TTR (0.81) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL26936583 | 0.89 | TTR (0.79) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL27670275 | 0.86 | TTR (0.74) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL26936729 | 0.84 | TTR (0.72) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL26936448 | 0.84 | TTR (0.72) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL27983148 | 0.84 | TTR (0.72) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL1616189 | 0.84 | TTR (1.00) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL31238528 | 0.84 | TTR (1.00) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL1869030 | 0.83 | ALDH1A1 (0.84) | TTRALDH1A1TSHRFDPSHPGD | |
| SCHEMBL17508149 | 0.82 | TTR (0.69) | TTRALDH1A1TSHRFDPSHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2450352-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER | Takeda Pharmaceutical Company Limited (JP) | 2012-05-09 | — | — | EP | disclosed |
| WO-2011016501-A1 | PROPHYLACTIC OR THERAPEUTIC AGENT FOR CANCER | 武田薬品工業株式会社 (JP) | 2011-02-10 | — | — | WO | disclosed |