Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 6/20 | 0.51 |
| ▸ | LAP3 | P28838 | 3/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4833512 | 1.00 | ALDH1A1 (0.62) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL31285799 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL6010356 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL28707844 | 0.89 | ALDH1A1 (0.58) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL11421008 | 0.87 | ALDH1A1 (0.56) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL11421004 | 0.87 | ALDH1A1 (0.56) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL4572627 | 0.86 | ALDH1A1 (0.64) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL29851595 | 0.86 | ALDH1A1 (0.64) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL6374251 | 0.86 | ALDH1A1 (0.64) | ALDH1A1MEN1LMNAKMT2AMAPT | |
| SCHEMBL14254618 | 0.85 | ALDH1A1 (0.55) | ALDH1A1MEN1LMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081274-A1 | MAST CELL-DERIVED RENIN | CORNELL RESEARCH FOUNDATION, INC. (US) | 2009-03-26 | — | — | US | disclosed |
| US-20080032918-A1 | Gene expression or biosynthesis inhibition by locally administering inhibitors of angiotensin-converting enzyme, angiotensin type 1 receptors, or sodium-hydrogen exchange type-1 proteins; antiinflammatory agents, myocardial antiischemic agents, anaphylaxis; sustained release implants, stents, inhalers | CORNELL RESEARCH FOUNDATION, INC. | 2008-02-07 | — | — | US | disclosed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| US-20050209141-A1 | Mast cell-derived renin | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-09-22 | — | — | US | disclosed |
| WO-2005037317-A2 | MAST CELL-DERIVED RENIN | CORNELL RESEARCH FOUNDATION, INC. (US) | 2005-04-28 | — | — | WO | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |
| EP-0243477-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-11-04 | — | — | EP | disclosed |
| WO-1987002581-A1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1987-05-07 | — | — | WO | disclosed |