Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28905014 | 0.84 | BTK (0.57) | ALDH1A1HPGDBTKTSHRRAB9A | |
| SCHEMBL3722968 | 0.81 | CYP11B1 (0.57) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 | |
| Hydrochloric Acid SCHEMBL9847505 | 0.80 | BTK (0.54) | ALDH1A1HPGDBTKTSHRRAB9A | |
| SCHEMBL31316504 | 0.79 | BTK (0.50) | ALDH1A1HPGDBTKTSHRRAB9A | |
| SCHEMBL4506402 | 0.78 | CYP11B1 (0.60) | CYP11B1CYP11B2TSHRRAB9AMAPT | |
| SCHEMBL22509832 | 0.78 | MEN1 (0.58) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL15958620 | 0.78 | ALDH1A1 (0.51) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL27977365 | 0.78 | CYP11B1 (0.57) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL27656250 | 0.78 | CYP11B1 (0.57) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 | |
| SCHEMBL2598829 | 0.78 | CYP11B1 (0.53) | ALDH1A1HPGDCYP11B1CYP11B2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081931-A2 | FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR | Amgen Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008008539-A2 | FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR | AMGEN INC. (US) | 2008-01-17 | — | — | WO | disclosed |