Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263684 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1MAPTTP53NPC1 | |
| SCHEMBL4264176 | 0.89 | CNR1 (0.42) | SMN1; SMN2NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL4264170 | 0.89 | CNR1 (0.42) | SMN1; SMN2NPSR1MAPTKDM4EALDH1A1 | |
| SCHEMBL4262298 | 0.86 | NPC1 (0.58) | SMN1; SMN2MAPTTP53NPC1ALDH1A1 | |
| SCHEMBL4262302 | 0.86 | NPC1 (0.58) | SMN1; SMN2MAPTTP53NPC1ALDH1A1 | |
| SCHEMBL4258752 | 0.82 | KMT2A (0.46) | MAPTKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL4258750 | 0.82 | KMT2A (0.46) | MAPTKDM4EALDH1A1LMNAPOLB | |
| SCHEMBL4265061 | 0.81 | MCHR1 (0.45) | SMN1; SMN2NPC1ALDH1A1AURKBCNR1 | |
| SCHEMBL4265059 | 0.81 | MCHR1 (0.45) | SMN1; SMN2NPC1ALDH1A1AURKBCNR1 | |
| SCHEMBL6876727 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1MAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | SMN1; SMN2 898/4885NPSR1 75/4885MAPT 412/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.