Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.37 |
| ▸ | CDK1 | P06493 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197483 | 0.87 | HDAC8 (0.41) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL3558801 | 0.86 | PLK1 (0.38) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL2199778 | 0.86 | PLK1 (0.38) | PLK1CDK1KDRIGF1RCDK2 | |
| SCHEMBL3552091 | 0.85 | PLK1 (0.38) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL3558617 | 0.84 | PLK1 (0.39) | PLK1CDK1KDRIGF1RCDK2 | |
| SCHEMBL2199169 | 0.83 | PLK1 (0.43) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL3546850 | 0.83 | PLK1 (0.47) | PLK1CDK1KDRIGF1RCDK2 | |
| SCHEMBL2196305 | 0.83 | PLK1 (0.37) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL2199959 | 0.83 | PLK1 (0.37) | PLK1CDK1KDRIGF1RHDAC8 | |
| SCHEMBL3549784 | 0.82 | CDK1 (0.44) | PLK1CDK1KDRIGF1RKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116543-A1 | NOVEL AMINOPYRIMIDINE DERIVATIVE AS PLK1 INHIBITOR | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2009-11-11 | — | — | EP | disclosed |