Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.38 |
| ▸ | CDK1 | P06493 | 5/20 | 0.35 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 3/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3552091 | 0.91 | PLK1 (0.38) | PLK1CDK1KDRKDM4EALDH1A1 | |
| SCHEMBL3558617 | 0.90 | PLK1 (0.39) | PLK1CDK1KDRKDM4EALDH1A1 | |
| SCHEMBL3546850 | 0.89 | PLK1 (0.47) | PLK1CDK1KDRALDH1A1HPGD | |
| SCHEMBL4257883 | 0.88 | ALDH1A1 (0.43) | PLK1CDK1KDRKDM4EALDH1A1 | |
| SCHEMBL3550499 | 0.88 | PLK1 (0.39) | PLK1RPS6KB1FLT3MAPK14 | |
| SCHEMBL3546619 | 0.88 | PLK1 (0.39) | PLK1CDK1KDRKDM4EALDH1A1 | |
| SCHEMBL3554854 | 0.88 | PLK1 (0.36) | PLK1CDK1KDRKDM4EALDH1A1 | |
| SCHEMBL2197483 | 0.88 | HDAC8 (0.41) | PLK1CDK1KDRALDH1A1HPGD | |
| SCHEMBL2199169 | 0.88 | PLK1 (0.43) | PLK1CDK1KDRALDH1A1HPGD | |
| SCHEMBL2199959 | 0.87 | PLK1 (0.37) | PLK1CDK1KDRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101048406-B | Novel substituted imidazole derivatives | BANYU PHARMA CO LTD | 2010-12-22 | — | — | CN | disclosed |
| US-7718801-B2 | Substituted imidazole derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | MSD K.K. (JP) | 2008-03-20 | — | — | US | disclosed |
| CN-101048406-A | Novel substituted imidazole derivatives | BANYU PHARMA CO LTD (JP) | 2007-10-03 | — | — | CN | disclosed |
| EP-1790650-A1 | NOVEL SUBSTITUTED IMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-05-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070894-A1 | Novel Substituted Imidazole Derivative | PLK1, CDK1, CDK11A | PLK1 1/4885CDK1 2/4885KDR 2133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.