Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Lobeline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.97 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.97 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lobeline SCHEMBL14029403 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL3308906 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL290804 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL13900378 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL290803 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL2905547 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL8305826 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL467021 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL8994428 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL467022 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3391884-B1 | TRANSDERMALLY ABSORBABLE PREPARATION | KM TRANSDERM LTD (JP) | 2024-04-10 | — | — | EP | disclosed |
| US-11786480-B2 | Transdermally absorbable preparation | KM Transderm Ltd. (JP) | 2023-10-17 | — | — | US | disclosed |
| EP-3040068-B1 | ADHESIVE SHEET FOR APPLICATION TO THE SKIN, AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME | KM TRANSDERM LTD (JP) | 2021-08-18 | — | — | EP | disclosed |
| EP-3254677-B1 | ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO (JP) | 2021-08-04 | — | — | EP | disclosed |
| US-20210062053-A1 | ADHESIVE SHEET FOR SKIN PATCH | KANEKA CORPORATION (JP) | 2021-03-04 | — | — | US | disclosed |
| EP-3744349-A1 | ADHESIVE SHEET FOR ATTACHMENT TO SKIN | Kaneka Corporation (JP) | 2020-12-02 | — | — | EP | disclosed |
| CN-107205957-B | Patch preparation | 久光制药株式会社 | 2020-12-01 | — | — | CN | disclosed |
| US-20200214991-A1 | ADHESIVE SHEET FOR APPLICATION TO THE SKIN, AND PERCUTANEOUS ABSORPTION PREPARATION USING SAME | KM Transderm Ltd. (JP) | 2020-07-09 | — | — | US | disclosed |
| US-10314791-B2 | Adhesive sheet for attachment to skin and percutaneous absorption preparation using same | KM Transderm Ltd. (JP) | 2019-06-11 | — | — | US | disclosed |
| US-10292941-B2 | Adhesive patch | HITSAMITSU PHARMACEUTICAL CO., INC. (JP) | 2019-05-21 | — | — | US | disclosed |
| US-20130226112-A1 | PERCUTANEOUS ABSORBENT AND ADHESIVE SHEET FOR SKIN PATCH | MEDRX CO., LTD. (JP) | 2013-08-29 | — | — | US | disclosed |
| EP-2614819-A1 | PERCUTANEOUS ABSORBENT AND ADHESIVE SHEET FOR SKIN PATCH | KM Transderm (JP) | 2013-07-17 | — | — | EP | disclosed |
| EP-1806152-B1 | Drug for external use and adhesive patch | HISAMITSU PHARMACEUTICAL CO (JP) | 2012-08-01 | — | — | EP | disclosed |
| EP-1806151-B1 | DRUG FOR EXTERNAL USE AND ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO (JP) | 2012-05-23 | — | — | EP | disclosed |
| US-20090238860-A1 | Adhesive Patch Less Irritative to Skin | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2009-09-24 | — | — | US | disclosed |
| EP-1925299-A1 | ADHESIVE PATCH LESS IRRITATIVE TO SKIN | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2008-05-28 | — | — | EP | disclosed |
| US-20080089925-A1 | Drug for External Use and Adhesive Patch | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2008-04-17 | — | — | US | disclosed |
| US-20070298089-A1 | Drug for External Use and Adhesive Patch | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2007-12-27 | — | — | US | disclosed |
| EP-1806151-A1 | DRUG FOR EXTERNAL USE AND ADHESIVE PATCH | Hisamitsu Pharmaceutical Co., Ltd. (JP) | 2007-07-11 | — | — | EP | disclosed |
| EP-1806152-A1 | DRUG FOR EXTERNAL USE AND ADHESIVE PATCH | HISAMITSU PHARMACEUTICAL CO., INC. (JP) | 2007-07-11 | — | — | EP | disclosed |