Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 1/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.97 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.97 |
| ▸ | HTR2A | P28223 | 1/20 | 0.97 |
| ▸ | HRH1 | P35367 | 1/20 | 0.97 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.97 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.97 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.97 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lobeline SCHEMBL290803 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL8305826 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL14029403 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL290804 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL3308906 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL2905547 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL13900378 | 0.99 | CYP2D6 (1.00) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL467021 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL4264391 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA | |
| Lobeline SCHEMBL467022 | 0.97 | CYP2D6 (0.97) | CYP2D6CYP1A2TSHRNFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0725640-A1 | USE OF LOBELINE FOR THE TREATMENT OF NICOTINE WITHDRAWAL | DYNAGEN, INC. (US) | 1996-08-14 | — | — | EP | disclosed |
| WO-1995011679-A1 | USE OF LOBELINE FOR THE TREATMENT OF NICOTINE WITHDRAWAL | DYNAGEN, INC. (US) | 1995-05-04 | — | — | WO | disclosed |