Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2012106 | 1.00 | CTSL (0.36) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL2012110 | 1.00 | CTSL (0.36) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL7817931 | 0.81 | PDE4D (0.35) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL31629517 | 0.75 | CCNE1 (0.35) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL25946312 | 0.75 | CCNE1 (0.35) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL15673910 | 0.75 | CTSL (0.33) | CTSLCTSS | |
| SCHEMBL30934674 | 0.74 | CTSL (0.41) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL13757740 | 0.73 | CTSL (0.36) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL10137338 | 0.73 | CTSL (0.36) | CTSLCTSSMLNRABCB11LMNA | |
| SCHEMBL627444 | 0.73 | CTSL (0.36) | CTSLCTSSMLNRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114958-A1 | INHIBITORS OF SERINE PROTEASES FOR THE TREATMENT OF HCV INFECTIONS | Vertex Pharmceuticals Incorporated (US) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008106139-A1 | INHIBITORS OF SERINE PROTEASES FOR THE TREATMENT OF HCV INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-04 | — | — | WO | disclosed |