Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15343955 | 0.96 | CES2 (0.44) | RECQLBTKCES2CES1TSHR | |
| SCHEMBL6128504 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL17476756 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL13711830 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL254912 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL14438406 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL14210997 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL10306770 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL16169552 | 0.94 | BTK (0.44) | RECQLBTKTSHRANPEPGABRP | |
| SCHEMBL6914440 | 0.91 | BTK (0.43) | RECQLBTKTSHRANPEPGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471797-B1 | 17-DESMETHYLRAPAMYCIN AND ANALOGUES THEREOF, METHODS FOR THEIR PRODUCTION AND THEIR USE AS IMMUNOSUPRESSANTS, ANTICANCER AGENTS, ANTIFUNGAL AGENTS ETC. | BUCK INST FOR RES ON AGING (US) | 2016-02-03 | — | — | EP | disclosed |
| EP-2471797-A2 | 17-Desmethylrapamycin and analogues thereof, methods for their production and their use as immunosupressants, anticancer agents, antifungal agents etc. | Biotica Technology Limited (GB) | 2012-07-04 | — | — | EP | disclosed |
| EP-2029611-A2 | 17-DESMETHYLRAPAMYCIN AND ANALOGUES THEREOF, METHODS FOR THEIR PRODUCTION AND THEIR USE AS IMMUNOSUPRESSANTS, ANTICANCER AGENTS, ANTIFUNGAL AGENTS ETC. | Biotica Technology Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2006016167-A2 | 17-DESMETHYLRAPAMYCIN AND ANALOGUES THEREOF, METHODS FOR THEIR RODUCTION AND THEIR USE AS IMMUNOSUPRESSANTS, ANTICANCER AGENTS, ANTIFUNGAL AGENTS, ETC. | BIOTICA TECHNOLOGY LIMITED (GB) | 2006-02-16 | — | — | WO | disclosed |