Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | PAM | P19021 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10626718 | 0.79 | NPC1 (0.42) | MAOBRELAGRM5MEN1KMT2A | |
| SCHEMBL4267199 | 0.76 | BCHE (0.42) | MAOBRELAGRM5MEN1KMT2A | |
| SCHEMBL4831765 | 0.75 | EGFR (0.43) | RELALMNAMAPTHDAC3SMN1; SMN2 | |
| Boric Acid SCHEMBL28492772 | 0.75 | CA1 (0.44) | MAOBRELAKMT2AALDH1A1LMNA | |
| SCHEMBL11171879 | 0.74 | NPC1 (0.48) | MAOBRELAGRM5TRPA1NPC1 | |
| SCHEMBL136178 | 0.74 | NPC1 (0.48) | MAOBRELAGRM5TRPA1NPC1 | |
| SCHEMBL10628700 | 0.73 | EGFR (0.45) | LMNAMAPTHDAC3SMN1; SMN2NPC1 | |
| SCHEMBL303152 | 0.73 | EGFR (0.45) | LMNAMAPTHDAC3SMN1; SMN2NPC1 | |
| SCHEMBL10623988 | 0.73 | EGFR (0.45) | LMNAMAPTHDAC3SMN1; SMN2NPC1 | |
| SCHEMBL10628492 | 0.73 | EGFR (0.45) | LMNAMAPTHDAC3SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133195-B2 | Quaternary ammonium salt compounds of spirocyclopiperazines, preparation methods and uses thereof | PEKING UNIVERSITY (CN) | 2015-09-15 | — | — | US | disclosed |
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | PEKING UNIVERSITY (CN) | 2009-12-31 | — | — | US | disclosed |
| EP-2036909-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | Peking University (CN) | 2009-03-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325929-A1 | QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF | CHRM4, CHRM1, CHRNA4 | MAOB 1221/4885RELA 1710/4885GRM5 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.