Cyclic Adenosine Monophosphate

Cyclic Adenosine Monophosphate

SCHEMBL427065

Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1O.Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 14/20 1.00
LMNA P02545 2/20 1.00
RAPGEF3 O95398 2/20 1.00
KMT2A Q03164 2/20 1.00
GMNN O75496 1/20 1.00
BLM P54132 1/20 1.00
NPSR1 Q6W5P4 1/20 1.00
RAPGEF4 Q8WZA2 1/20 1.00
RXFP1 Q9HBX9 1/20 0.80
PDE4A P27815 1/20 0.78
PDE4B Q07343 1/20 0.78
PDE4C Q08493 1/20 0.78
PDE4D Q08499 1/20 0.78
MEN1 O00255 1/20 0.78
ALDH1A1 P00352 1/20 0.78

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cyclic Adenosine Monophosphate SCHEMBL18716064 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
SCHEMBL15893189 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
SCHEMBL18934079 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
SCHEMBL22434642 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829653 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829820 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829591 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829670 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL23829673 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN
Cyclic Adenosine Monophosphate SCHEMBL20912149 1.00 STING1 (1.00) STING1LMNARAPGEF3KMT2AGMNN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024103125-A1 METHOD OF MODIFYING CELLS ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY (AU) 2024-05-23 WO disclosed
WO-2024092321-A1 METHODS OF ENHANCING ENDOTHELIAL BARRIER INTEGRITY ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY (AU) 2024-05-10 WO disclosed
WO-2024064701-A2 ADENOSINE ANALOGS FOR THE TREATMENT OF DISEASE BIOINTERVENE, INC. (US) 2024-03-28 WO disclosed
US-20230293530-A1 AGENTS FOR SENSITIZING SOLID TUMORS TO TREATMENT YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) 2023-09-21 US disclosed
US-11753455-B2 Compounds for treatment of obesity NOVO NORDISK A/S (DK) 2023-09-12 US disclosed
US-20230203121-A1 Incretin Analogs and Uses Thereof ELI LILLY AND COMPANY 2023-06-29 US disclosed
US-11542313-B2 Incretin analogs and uses thereof ELI LILLY AND COMPANY (US) 2023-01-03 US disclosed
US-11390657-B2 Peptide analogs ADEPTHERA LLC (US) 2022-07-19 US disclosed
CN-112312922-A Novel compounds for the treatment of obesity 诺和诺德股份有限公司 2021-02-02 CN disclosed
US-20200339649-A1 PEPTIDE ANALOGS ADEPTHERA LLC 2020-10-29 US disclosed
EP-0705433-A4 COMPOSITIONS AND METHODS FOR ANTI-ADDICTIVE NARCOTIC ANALGESIS ACIVITY SCREENING AND TREATMENTS UNIV CALIFORNIA (US) 2001-09-26 EP disclosed
EP-1124829-A1 TRICYCLIC PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS ZAMBON GROUP S.p.A. (IT) 2001-08-22 EP disclosed
WO-2000026218-A1 TRICYCLIC PHTHALAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS ZAMBON GROUP S.P.A. (IT) 2000-05-11 WO disclosed
CN-1248295-A Species, genus specific and universal probes and primers for pathogen and related antibiotic resistance gene detection for diagnosis INFECTIO DIAGNOSTIC INC (CA) 2000-03-22 CN disclosed
EP-0943009-A2 SPECIES-SPECIFIC, GENUS-SPECIFIC AND UNIVERSAL DNA PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL AND FUNGAL PATHOGENS AND ASSOCIATED ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR DIAGNOSIS IN MICROBIOLOGY LABORATORIES Infectio Diagnostic (I.D.I.) INC. (CA) 1999-09-22 EP disclosed
WO-1998043992-A1 CYCLIC ADENOSINE DIPHOSPHATE RIBOSE ANALOGUES ISIS INNOVATION LIMITED (GB) 1998-10-08 WO disclosed
WO-1998020157-A2 SPECIES-SPECIFIC, GENUS-SPECIFIC AND UNIVERSAL DNA PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL AND FUNGAL PATHOGENS AND ASSOCIATED ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR DIAGNOSIS IN MICROBIOLOGY LABORATORIES INFECTIO DIAGNOSTIC (I.D.I.) INC. (CA) 1998-05-14 WO disclosed
EP-0705433-A1 COMPOSITIONS AND METHODS FOR ANTI-ADDICTIVE NARCOTIC ANALGESIS ACIVITY SCREENING AND TREATMENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1996-04-10 EP disclosed
WO-1995000848-A1 COMPOSITIONS AND METHODS FOR ANTI-ADDICTIVE NARCOTIC ANALGESIS ACIVITY SCREENING AND TREATMENTS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-01-05 WO disclosed
US-4950680-A SYNERGISTIC ADMIXTURE OF A 1,4-DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKER, AND A PROSTACYCLIN BOARD OF GOVERNORS OF WAYNE STATE UNIVERSITY (US) 1990-08-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339649-A1 PEPTIDE ANALOGS RAMP1, RAMP2, RAMP3 STING1 626/4885LMNA 2624/4885RAPGEF3 838/4885
US-11753455-B2 Compounds for treatment of obesity GLP1R, TFRC, GIPR STING1 3871/4885LMNA 3960/4885RAPGEF3 1305/4885
US-11542313-B2 Incretin analogs and uses thereof GLP1R, GIPR, GCGR STING1 3321/4885LMNA 2597/4885RAPGEF3 1052/4885
US-20230203121-A1 Incretin Analogs and Uses Thereof GLP1R, GIPR, GCGR STING1 3321/4885LMNA 2597/4885RAPGEF3 1052/4885
US-11390657-B2 Peptide analogs RAMP1, RAMP3, RAMP2 STING1 824/4885LMNA 3399/4885RAPGEF3 712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.