Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tert-Butylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylamine SCHEMBL3628885 | 0.85 | ALDH1A1 (0.41) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| SCHEMBL2319771 | 0.83 | ALDH1A1 (0.35) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| SCHEMBL4321722 | 0.83 | TAAR1 (0.37) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| Benzene SCHEMBL31091106 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| SCHEMBL143876 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| SCHEMBL11707018 | 0.82 | ALDH1A1 (0.50) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| Methylamine SCHEMBL30143867 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRLMNANPSR1MAPT | |
| SCHEMBL31697703 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPK1TSHRLMNANPSR1 | |
| SCHEMBL10587125 | 0.79 | ALDH1A1 (0.41) | ALDH1A1TSHRLMNANPSR1MAPT | |
| SCHEMBL701137 | 0.79 | MAPK1 (0.32) | ALDH1A1MAPK1LMNANPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114479227-B | Polyolefin composition and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-06-04 | — | — | CN | claimed |
| CN-114478889-B | Ethylene polymer and preparation method and application thereof | 中国石油化工股份有限公司 | 2024-06-04 | — | — | CN | claimed |
| CN-115362187-A | Polyethylene compositions obtained using transition metal bis (phenolate) catalyst complexes and homogeneous processes for producing the same | 埃克森美孚化学专利公司 | 2022-11-18 | — | — | CN | claimed |
| CN-115315452-A | Propylene polymers obtained using transition metal bis (phenolate) catalyst complexes and homogeneous processes for producing the same | 埃克森美孚化学专利公司 | 2022-11-08 | — | — | CN | claimed |
| CN-115315455-A | Ethylene-alpha-olefin-diene monomer copolymers obtained using transition metal bis (phenolate) catalyst complexes and homogeneous processes for producing the same | 埃克森美孚化学专利公司 | 2022-11-08 | — | — | CN | claimed |
| CN-115315453-A | Propylene copolymers obtained using transition metal bis (phenolate) catalyst complexes and homogeneous processes for producing the same | 埃克森美孚化学专利公司 | 2022-11-08 | — | — | CN | claimed |
| CN-114929761-A | With C 1 Isotactic propylene homopolymers and copolymers produced by symmetric metallocene catalysts | 埃克森美孚化学专利公司 | 2022-08-19 | — | — | CN | claimed |
| CN-114867758-A | Metallocenes and methods thereof | 埃克森美孚化学专利公司 | 2022-08-05 | — | — | CN | claimed |
| CN-114479227-A | Polyolefin composition and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114478889-A | Ethylene polymer and preparation method and application thereof | 中国石油化工股份有限公司 | 2022-05-13 | — | — | CN | claimed |
| CN-113874401-A | Metallocenes containing two-SI-SI-bridges | 埃克森美孚化学专利公司 | 2021-12-31 | — | — | CN | claimed |
| CN-113614123-A | Transition metal bis (phenolate) complexes and their use as olefin polymerization catalysts | 埃克森美孚化学专利公司 | 2021-11-05 | — | — | CN | claimed |
| CN-113423742-A | Bis (arylphenolate) lewis base catalysts and processes thereof | 埃克森美孚化学专利公司 | 2021-09-21 | — | — | CN | claimed |
| CN-113423744-A | Lewis base catalyst and process therefor | 埃克森美孚化学专利公司 | 2021-09-21 | — | — | CN | claimed |
| CN-110799477-A | Preparation of olefin dimers | 埃克森美孚化学专利公司 | 2020-02-14 | — | — | CN | claimed |
| CN-101124235-A | Olefin polymerization catalyst system and method of using same | EXXONMOBIL CHEM PATENTS INC (US) | 2008-02-13 | — | — | CN | claimed |
| CN-114555543-B | Process for preparing poly-alpha-olefins and apparatus therefor | 埃克森美孚化学专利公司 | 2024-07-12 | — | — | CN | disclosed |
| CN-118202023-A | Polypropylene viscosity modifier and lubricating oil thereof | 埃克森美孚化学专利公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-1997044371-A1 | POLYOLEFIN COMPOSITION WITH MOLECULAR WEIGHT MAXIMUM OCCURING IN THAT PART OF THE COMPOSITION THAT HAS THE HIGHEST COMONOMER CONTENT | THE DOW CHEMICAL COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |
| US-4001279-A | CARRY INSOLUBLE REAGENT SUBSTANCES INTO SOLUTION IN NON-HYDROXYLIC MEDIA; CROWN COMPOUNDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1977-01-04 | — | — | US | disclosed |