Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | MTOR | P42345 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303766 | 1.00 | SMN1; SMN2 (0.39) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302528 | 0.89 | MAPT (0.39) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL303591 | 0.89 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMEN1CA12CA1 | |
| SCHEMBL303780 | 0.89 | BRAF (0.37) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302382 | 0.87 | ALDH1A1 (0.44) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302239 | 0.85 | KDM4E (0.41) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302237 | 0.85 | KDM4E (0.41) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302488 | 0.85 | ALDH1A1 (0.39) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302346 | 0.84 | CA12 (0.36) | SMN1; SMN2MAPTKMT2AMEN1CA12 | |
| SCHEMBL302309 | 0.84 | ATR (0.42) | SMN1; SMN2KMT2AMEN1BRAFATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021434-A1 | METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS | SYNTA PHARMACEUTICALS CORP. (US) | 2012-01-26 | — | — | US | disclosed |
| EP-1689403-A4 | HETEROARYL-HYDRAZONE COMPOUNDS | SYNTA PHARMACEUTICALS CORP (US) | 2007-09-05 | — | — | EP | disclosed |
| EP-1689403-A2 | HETEROARYL-HYDRAZONE COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2006-08-16 | — | — | EP | disclosed |
| WO-2005046604-A2 | HETEROARYL-HYDRAZONE COMPOUNDS | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-05-26 | — | — | WO | disclosed |