Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 19/20 | 0.77 |
| ▸ | MEN1 | O00255 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.68 |
| ▸ | RECQL | P46063 | 2/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CASP1 | P29466 | 2/20 | 0.65 |
| ▸ | CASP7 | P55210 | 2/20 | 0.65 |
| ▸ | HBB | P68871 | 2/20 | 0.65 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.65 |
| ▸ | USP2 | O75604 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483239 | 0.94 | TOP1 (0.77) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL8479521 | 0.91 | TOP1 (0.73) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL8484504 | 0.90 | TOP1 (0.72) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL27477906 | 0.90 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL8481388 | 0.90 | TOP1 (0.78) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL27477507 | 0.90 | TOP1 (0.78) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL8481436 | 0.90 | TOP1 (0.80) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL4259431 | 0.90 | TOP1 (0.76) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL27367949 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2RECQL | |
| SCHEMBL4264482 | 0.89 | TOP1 (0.70) | TOP1MEN1KMT2ASMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096113-A1 | 9-substituted camptothecin derivatives as antitumor compounds | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-09-02 | — | — | EP | claimed |
| EP-2096113-A1 | 9-substituted camptothecin derivatives as antitumor compounds | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2009-09-02 | — | — | EP | disclosed |