Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ADH1B | P00325 | 1/20 | 0.32 |
| ▸ | ADH1C | P00326 | 1/20 | 0.32 |
| ▸ | ADH1A | P07327 | 1/20 | 0.32 |
| ▸ | ADH4 | P08319 | 1/20 | 0.32 |
| ▸ | ADH7 | P40394 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | FAAH | O00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202332 | 0.86 | TSHR (0.44) | TSHRALDH1A1 | |
| SCHEMBL13834842 | 0.86 | TSHR (0.40) | TSHRALDH1A1 | |
| SCHEMBL10456115 | 0.85 | TSHR (0.45) | TSHRFFAR1FFAR4MEN1CYP3A4 | |
| SCHEMBL564664 | 0.81 | TSHR (0.42) | TSHRALDH1A1ADH1BADH1CADH1A | |
| SCHEMBL25172364 | 0.79 | TSHR (0.46) | TSHRALDH1A1ADH1BADH1CADH1A | |
| SCHEMBL4556969 | 0.79 | TSHR (0.46) | TSHRALDH1A1ADH1BADH1CADH1A | |
| SCHEMBL1615226 | 0.79 | TSHR (0.46) | TSHRALDH1A1ADH1BADH1CADH1A | |
| SCHEMBL6061890 | 0.79 | ADH1B (0.36) | TSHRADH1BADH1CADH1AADH4 | |
| SCHEMBL632478 | 0.79 | TSHR (0.46) | TSHRALDH1A1ADH1BADH1CADH1A | |
| SCHEMBL4634958 | 0.79 | ADH1B (0.36) | TSHRADH1BADH1CADH1AADH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009067493-A2 | 1,3,5 TRI-SUBTITUTED BENZENES FOR TREATMENT OF ALZHEIMER'S DISEASE AND OTHER DISORDERS | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-05-28 | — | — | WO | claimed |
| EP-1830869-A1 | METHOD OF TREATMENT OR PROPHYLAXIS | THE UNIVERSITY OF QUEENSLAND (AU) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066361-A1 | METHOD OF TREATMENT OR PROPHYLAXIS | THE UNIVERSITY OF QUEENSLAND (AU) | 2006-06-29 | — | — | WO | claimed |