Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBS | P35520 | 1/20 | 0.96 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3486974 | 0.98 | CBS (1.00) | CBSPTGS2CYP3A4LTA4HACHE | |
| SCHEMBL31545757 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL31546072 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL31545858 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL164545 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL9472976 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL15151838 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL31544875 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL31545471 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE | |
| SCHEMBL31545744 | 0.91 | CBS (0.79) | CBSPTGS2CYP3A4ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081119-A1 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-03-26 | — | — | US | claimed |
| WO-2007001684-A9 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIV PITTSBURGH (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007001684-A2 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-04 | — | — | WO | claimed |
| US-20090081119-A1 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-03-26 | — | — | US | disclosed |
| WO-2007001684-A9 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIV PITTSBURGH (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007001684-A2 | INHIBITING DNA POLYMERASE BETA TO ENHANCE EFFICACY OF ANTICANCER AGENTS | UNIVERSITY OF PITTSBURGH OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2007-01-04 | — | — | WO | disclosed |