Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.91 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meglumine SCHEMBL12195402 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL18270062 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL20836266 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23363691 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL724392 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23106596 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL22641548 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23363692 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL22562873 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL14126374 | 0.95 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2068956-B1 | MEDICAL DEVICES FOR RELEASE OF LOW SOLUBILITY THERAPEUTIC AGENTS | BOSTON SCIENT LTD (BM) | 2017-03-01 | — | — | EP | disclosed |
| EP-2068956-A2 | MEDICAL DEVICES FOR RELEASE OF LOW SOLUBILITY THERAPEUTIC AGENTS | Boston Scientific Limited (BB) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008002434-A2 | MEDICAL DEVICES FOR RELEASE OF LOW SOLUBILITY THERAPEUTIC AGENTS | BOSTON SCIENTIFIC SCIMED, INC. (US) | 2008-01-03 | — | — | WO | disclosed |
| US-20070298069-A1 | Medical devices for release of low solubility therapeutic agents | BOSTON SCIENTIFIC SCIMED, INC. | 2007-12-27 | — | — | US | disclosed |
| US-5028625-A | Chewable Tablet For Oral Administration | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-07-02 | — | — | US | disclosed |