Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Meglumine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Meglumine SCHEMBL18270062 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL14126374 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL12195402 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL22641548 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23363692 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL724392 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23106596 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL20836266 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL23363691 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 | |
| Meglumine SCHEMBL5584 | 1.00 | KDM4E (1.00) | KDM4ELMNAL3MBTL1TDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220096978-A1 | METHOD FOR PRODUCING AN ORGANIC SOLVENT | NISSAN CHEMICAL CORPORATION (JP) | 2022-03-31 | — | — | US | disclosed |
| US-20210397091-A1 | METHOD FOR PRODUCING COATING FILM-FORMING COMPOSITION FOR LITHOGRAPHY | NISSAN CHEMICAL CORPORATION (JP) | 2021-12-23 | — | — | US | disclosed |
| EP-3386953-B1 | CONTRAST AGENTS | BRACCO IMAGING SPA (IT) | 2020-10-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220096978-A1 | METHOD FOR PRODUCING AN ORGANIC SOLVENT | ACMSD, SORD, IMPDH2 | KDM4E 681/4885LMNA 2848/4885L3MBTL1 2340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.