Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4274709 | 1.00 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL4274784 | 0.85 | ALDH1A1 (0.48) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1849895 | 0.84 | ALDH1A1 (0.47) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1853484 | 0.84 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1854249 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1851342 | 0.82 | ALDH1A1 (0.50) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL4113379 | 0.78 | CYP2C9 (0.46) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL4119378 | 0.78 | CYP2C9 (0.46) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL1855333 | 0.74 | NPSR1 (0.49) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL1849965 | 0.74 | NPSR1 (0.49) | KDM4EALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |