SCHEMBL4274602

SCHEMBL4274602

NC(=O)c1ccc(Cl)c(C(=O)Nc2ccc3[nH]ccc3c2)c1

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAOB P27338 5/20 0.65
MAOA P21397 4/20 0.65
NPC1 O15118 4/20 0.57
RAB9A P51151 4/20 0.57
MAPT P10636 3/20 0.56
CFTR P13569 1/20 0.50
PRKCI P41743 1/20 0.50
HDAC8 Q9BY41 1/20 0.47
BCAT2 O15382 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1351091 0.83 NPC1 (0.54) MAOBMAOANPC1RAB9AMAPT
SCHEMBL4107604 0.81 BRAF (0.61) MAOBMAOAHDAC8BCAT2
SCHEMBL15875737 0.79 MAOB (1.00) MAOBMAOANPC1RAB9AMAPT
SCHEMBL1354136 0.78 HDAC8 (0.74) NPC1HDAC8BCAT2
SCHEMBL170646 0.76 F2 (0.68) MAOBMAOANPC1RAB9AMAPT
SCHEMBL27522161 0.76 F2 (0.68) MAOBMAOANPC1RAB9AMAPT
SCHEMBL29540009 0.76 F2 (0.68) MAOBMAOANPC1RAB9AMAPT
SCHEMBL4716837 0.76 MAOB (0.71) MAOBMAOANPC1RAB9AMAPT
SCHEMBL30026512 0.74 NPC1 (0.63) MAOBMAOANPC1RAB9AMAPT
SCHEMBL1576877 0.74 NPC1 (0.63) MAOBMAOANPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2064213-A1 HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2009-06-03 EP claimed
WO-2008028617-A1 HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2008-03-13 WO claimed
EP-2064213-A1 HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS F. Hoffmann-La Roche AG (CH) 2009-06-03 EP disclosed
WO-2008028617-A1 HETEROARYL DERIVATIVES AS PROTEIN KINASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2008-03-13 WO disclosed