Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | CCR1 | P32246 | 1/20 | 0.30 |
| ▸ | CCR5 | P51681 | 1/20 | 0.30 |
| ▸ | CCR8 | P51685 | 1/20 | 0.30 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14366752 | 0.80 | AGXT (0.40) | HSP90AA1HSP90AB1AGXTNOS3NOS1 | |
| SCHEMBL3394671 | 0.79 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1AGXTCCR1CCR5 | |
| SCHEMBL3394039 | 0.79 | HSP90AA1 (0.40) | HSP90AA1HSP90AB1AGXTCCR1CCR5 | |
| SCHEMBL27661665 | 0.76 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1AGXT | |
| SCHEMBL5606343 | 0.75 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1AGXTNOS3NOS1 | |
| SCHEMBL15392290 | 0.75 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1AGXTNOS3NOS1 | |
| SCHEMBL1056427 | 0.72 | AGXT (0.69) | HSP90AA1HSP90AB1AGXT | |
| SCHEMBL4865054 | 0.71 | LMNA (0.38) | HSP90AA1HSP90AB1AGXTNOS3NOS1 | |
| Hydrochloric Acid SCHEMBL1061557 | 0.71 | AGXT (0.67) | HSP90AA1HSP90AB1AGXT | |
| SCHEMBL14438203 | 0.70 | CCR1 (0.36) | HSP90AA1HSP90AB1NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012791-A2 | 7,9-DIHYDRO-PURIN-8-ONE AND RELATED ANALOGS AS HSP90-INHIBITORS | Conforma Therapeutics Corporation (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070253896-A1 | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-11-01 | — | — | US | disclosed |
| WO-2007092496-A2 | 7,9-DIHYDRO-PURIN-8-ONE AND RELATED ANALOGS AS HSP90-INHIBITORS | CONFORMA THERAPEUTICS CORPORATION (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070253896-A1 | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors | HSP90B1, HSP90AB2P, HSP90AB1 | HSP90AA1 4/4885HSP90AB1 3/4885AGXT 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.