Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.62 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275413 | 0.91 | PTGDR2 (0.60) | PTGDR2ABCB1CASREPHX2KCNA5 | |
| SCHEMBL4272587 | 0.91 | PTGDR2 (0.74) | PTGDR2CASRGAALPAR1HTT | |
| SCHEMBL3166366 | 0.87 | PTGDR2 (0.82) | PTGDR2EPHX2KCNA5GAATSHR | |
| SCHEMBL3176899 | 0.87 | PTGDR2 (0.59) | PTGDR2ABCB1CASREPHX2KCNA5 | |
| SCHEMBL4272486 | 0.85 | PTGDR2 (0.66) | PTGDR2CASRLPAR1HTTLMNA | |
| SCHEMBL12678756 | 0.85 | PTGDR2 (0.66) | PTGDR2KCNA5TSHRLPAR1GPR132 | |
| SCHEMBL4273938 | 0.84 | PTGDR2 (0.61) | PTGDR2CASRHTTLMNAALDH1A1 | |
| SCHEMBL4272063 | 0.84 | PTGDR2 (0.78) | PTGDR2CASRGAALPAR1HTT | |
| SCHEMBL4266983 | 0.84 | PTGDR2 (0.65) | PTGDR2CASRLPAR1LMNAALDH1A1 | |
| SCHEMBL4274292 | 0.84 | PTGDR2 (0.65) | PTGDR2CASRLPAR1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |