Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.60 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.41 |
| ▸ | CASR | P41180 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4275411 | 0.91 | PTGDR2 (0.62) | PTGDR2KCNA5CASREPHX2GAA | |
| SCHEMBL4272589 | 0.91 | PTGDR2 (0.71) | PTGDR2CASRGAALPAR1HTT | |
| SCHEMBL3176899 | 0.87 | PTGDR2 (0.59) | PTGDR2KCNA5CASREPHX2GAA | |
| SCHEMBL3166366 | 0.86 | PTGDR2 (0.82) | PTGDR2KCNA5EPHX2GAATSHR | |
| SCHEMBL4266987 | 0.85 | PTGDR2 (0.63) | PTGDR2CASRLPAR1LMNA | |
| SCHEMBL4275484 | 0.85 | PTGDR2 (0.63) | PTGDR2CASRLPAR1HTTLMNA | |
| SCHEMBL4271817 | 0.84 | PTGDR2 (0.59) | PTGDR2CASRLPAR1HTTLMNA | |
| SCHEMBL4281837 | 0.83 | PTGDR2 (0.59) | PTGDR2CASR | |
| SCHEMBL4283351 | 0.83 | PTGDR2 (0.59) | PTGDR2CASRGAALPAR1 | |
| SCHEMBL12678756 | 0.83 | PTGDR2 (0.66) | PTGDR2KCNA5TSHRLPAR1GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |