Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 8/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4276043 | 0.93 | PTGDR2 (0.43) | FFAR4FFAR1PTGDR2CNR1PPARG | |
| SCHEMBL4270407 | 0.83 | PTGDR2 (0.41) | FFAR1PTGDR2PPARGPPARD | |
| SCHEMBL4283671 | 0.80 | FFAR4 (0.38) | FFAR4FFAR1PTGDR2CNR1LTB4R | |
| SCHEMBL3172653 | 0.79 | PTGDR2 (0.64) | FFAR4FFAR1PTGDR2CNR1LTB4R | |
| SCHEMBL4268388 | 0.77 | PTGDR2 (0.42) | PTGDR2PPARGPPARA | |
| SCHEMBL4277978 | 0.76 | DAO (0.34) | PTGDR2PPARGPPARA | |
| SCHEMBL3180242 | 0.75 | PTGDR2 (0.64) | FFAR4FFAR1PTGDR2LTB4RPPARG | |
| SCHEMBL4274009 | 0.75 | PTGDR2 (0.55) | FFAR1PTGDR2PTGDR | |
| SCHEMBL4268576 | 0.75 | PTGDR2 (0.46) | FFAR4FFAR1PTGDR2LTB4RPTGDR | |
| SCHEMBL4271758 | 0.74 | PTGDR2 (0.47) | FFAR4FFAR1PTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |