Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.58 |
| ▸ | CASR | P41180 | 11/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3165165 | 0.89 | PTGDR2 (0.75) | PTGDR2CASRNR3C1LPAR1DRD2 | |
| SCHEMBL4273831 | 0.89 | PTGDR2 (0.61) | PTGDR2CASR | |
| SCHEMBL4272587 | 0.87 | PTGDR2 (0.74) | PTGDR2CASRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4283355 | 0.87 | PTGDR2 (0.61) | PTGDR2CASRALDH1A1LPAR1 | |
| SCHEMBL4272486 | 0.82 | PTGDR2 (0.66) | PTGDR2CASRALDH1A1SMN1; SMN2LPAR1 | |
| SCHEMBL4273938 | 0.81 | PTGDR2 (0.61) | PTGDR2CASRALDH1A1SMN1; SMN2 | |
| SCHEMBL4266983 | 0.81 | PTGDR2 (0.65) | PTGDR2CASRALDH1A1SMN1; SMN2LPAR1 | |
| SCHEMBL4272063 | 0.81 | PTGDR2 (0.78) | PTGDR2CASRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL4274292 | 0.81 | PTGDR2 (0.65) | PTGDR2CASRALDH1A1SMN1; SMN2LPAR1 | |
| SCHEMBL4275411 | 0.81 | PTGDR2 (0.62) | PTGDR2CASRALDH1A1LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |