Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | OGA | O60502 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | PLAT | P00750 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4289740 | 0.99 | POLB (0.47) | POLBFDPSTP53OGAGAA | |
| SCHEMBL4283271 | 0.91 | POLB (0.56) | POLBTP53GAAMAPTKMT2A | |
| SCHEMBL4563945 | 0.84 | POLB (0.48) | POLBTP53OGAGAAWNT1 | |
| SCHEMBL3738441 | 0.83 | NPC1 (0.62) | POLBKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL4288598 | 0.83 | KMT2A (0.61) | POLBTP53GAACYP3A4MAPT | |
| Hydrochloric Acid SCHEMBL3731968 | 0.83 | NPC1 (0.61) | POLBKMT2AMEN1NPC1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4279918 | 0.83 | KMT2A (0.60) | POLBTP53GAACYP3A4MAPT | |
| SCHEMBL4285057 | 0.82 | MAPT (0.60) | POLBGAACYP3A4MAPTKMT2A | |
| SCHEMBL4284053 | 0.82 | GAA (0.57) | GAACYP3A4MAPTKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL4279689 | 0.81 | MAPT (0.59) | POLBGAACYP3A4MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | claimed |
| WO-2009150196-A1 | N-THIAZOLYL-1, 2, 3, 4-TETRAHYDRO-6-ISOQUINOLINECARBOXAMIDE DERIVATIVES AS INHIBITORS OF STEAROYL COENZYME A DESATURASE | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-17 | — | — | WO | disclosed |