Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 2/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733219 | 0.89 | RBP4 (0.35) | RARBRARGPLA2G2AALDH1A1RBP4 | |
| SCHEMBL309170 | 0.87 | IDO1 (0.41) | RBP4 | |
| SCHEMBL1815579 | 0.87 | IDO1 (0.41) | RBP4 | |
| SCHEMBL310131 | 0.73 | IDO1 (0.43) | RBP4 | |
| SCHEMBL1812127 | 0.73 | IDO1 (0.43) | RBP4 | |
| SCHEMBL731730 | 0.71 | HDAC3 (0.39) | RARBRARGPLA2G2ARBP4RARA | |
| SCHEMBL732818 | 0.66 | IDO1 (0.43) | — | |
| SCHEMBL309247 | 0.65 | KMT2A (0.49) | ALDH1A1 | |
| SCHEMBL743373 | 0.64 | IDO1 (0.43) | — | |
| SCHEMBL732811 | 0.64 | IDO1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120569-A2 | SPIROCHROMANON DERIVATIVES | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008088692-A2 | SPIROCHROMANON DERIVATIVES | MERCK & CO., INC. (US) | 2008-07-24 | — | — | WO | disclosed |