Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4273938 | 0.88 | PTGDR2 (0.61) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3174387 | 0.86 | PTGDR2 (0.72) | PTGDR2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL3168965 | 0.86 | PTGDR2 (0.51) | PTGDR2KDM4EMEN1KMT2ALMNA | |
| SCHEMBL4272587 | 0.84 | PTGDR2 (0.74) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL12678766 | 0.83 | PTGDR2 (0.58) | PTGDR2KDM4ECCR5MEN1KMT2A | |
| SCHEMBL4281806 | 0.81 | PTGDR2 (0.54) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4272486 | 0.80 | PTGDR2 (0.66) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4272063 | 0.80 | PTGDR2 (0.78) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL4266983 | 0.80 | PTGDR2 (0.65) | PTGDR2MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4274292 | 0.80 | PTGDR2 (0.65) | PTGDR2MAPTSMN1; SMN2ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |