Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10105094 | 1.00 | TRPV1 (0.47) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL13619643 | 1.00 | TRPV1 (0.47) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL38831 | 0.89 | ERCC1 (0.42) | POLBMEN1KMT2AACHEBACE1 | |
| SCHEMBL38357 | 0.89 | ERCC1 (0.42) | POLBMEN1KMT2AACHEBACE1 | |
| SCHEMBL42564 | 0.88 | TRPV1 (0.47) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL41897 | 0.88 | TRPV1 (0.47) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL41898 | 0.88 | TRPV1 (0.47) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL43612 | 0.88 | TRPV1 (0.49) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL47188 | 0.88 | TRPV1 (0.49) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 | |
| SCHEMBL42608 | 0.86 | TRPV1 (0.48) | TRPV1CYP3A4CYP2C19CYP1A2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484664-B1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO (JP) | 2013-09-04 | — | — | EP | claimed |
| US-8367835-B2 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-02-05 | — | — | US | claimed |
| EP-2484664-A1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-08-08 | — | — | EP | claimed |
| US-20120028937-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2012-02-02 | — | — | US | claimed |
| EP-2277861-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-01-26 | — | — | EP | claimed |
| EP-2484664-B1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO (JP) | 2013-09-04 | — | — | EP | disclosed |
| US-8367835-B2 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| EP-2484664-A1 | Cyclic amine-1-carboxylic acid ester derivative and pharmaceutical composition containing the same | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2012-08-08 | — | — | EP | disclosed |
| US-20120028937-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2277861-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2011-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028937-A1 | CYCLIC AMINE-1-CARBOXYLIC ACID ESTER DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | HRH3, ARG1, CNR1 | TRPV1 247/4885CYP3A4 1879/4885CYP2C19 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.