Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | RAF1 | P04049 | 3/20 | 0.47 |
| ▸ | KRAS | P01116 | 2/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4271182 | 0.81 | BRAF (0.43) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL4562970 | 0.80 | BRAF (0.42) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1521767 | 0.80 | BRAF (0.53) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1521806 | 0.79 | BRAF (0.46) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL4276058 | 0.79 | BRAF (0.45) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1521899 | 0.79 | BRAF (0.52) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL4273927 | 0.79 | BRAF (0.52) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1522009 | 0.78 | BRAF (0.56) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1521795 | 0.78 | BRAF (0.47) | BRAFKDRRAF1KRASMAP2K2 | |
| SCHEMBL1521556 | 0.77 | BRAF (0.52) | BRAFKDRRAF1KRASMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2063896-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | Deciphera Pharmaceuticals, LLC. (US) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008033999-A2 | KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-03-20 | — | — | WO | disclosed |