Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | KRAS | P01116 | 2/20 | 0.46 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.42 |
| ▸ | CNR2 | P34972 | 4/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | NEK7 | Q8TDX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521549 | 0.84 | BRAF (0.43) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL4277338 | 0.79 | BRAF (0.47) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521793 | 0.77 | BRAF (0.48) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521946 | 0.76 | ABL1 (0.52) | BRAFKDRRAF1MAPK14MAPK13 | |
| SCHEMBL1521666 | 0.76 | BRAF (0.47) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521767 | 0.76 | BRAF (0.53) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1522009 | 0.75 | BRAF (0.56) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521899 | 0.75 | BRAF (0.52) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521795 | 0.75 | BRAF (0.47) | BRAFKDRKRASRAF1MAP2K2 | |
| SCHEMBL1521670 | 0.75 | BRAF (0.51) | BRAFKDRKRASRAF1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | claimed |