Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | IDE | P14735 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | TK2 | O00142 | 2/20 | 0.48 |
| ▸ | TK1 | P04183 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38652488 | 0.88 | F2 (0.64) | TDP1F2TK1 | |
| Biotin SCHEMBL523980 | 0.83 | TDP1 (0.51) | TDP1LMNAMEN1ABL1PKM | |
| Doxribtimine SCHEMBL2985309 | 0.81 | TK1 (0.65) | LMNATK2TK1SMN1; SMN2 | |
| SCHEMBL6534840 | 0.80 | TK1 (0.46) | TDP1LMNAMEN1ABL1PKM | |
| Doxribtimine SCHEMBL20214217 | 0.79 | TK1 (0.69) | LMNATK2TK1SMN1; SMN2 | |
| Doxribtimine SCHEMBL28151767 | 0.78 | TK1 (0.72) | LMNAPKMTK2TK1SMN1; SMN2 | |
| Doxribtimine SCHEMBL8023808 | 0.78 | TK1 (0.72) | LMNAPKMTK2TK1SMN1; SMN2 | |
| Doxribtimine SCHEMBL993448 | 0.78 | TK1 (0.67) | LMNATK2TK1SMN1; SMN2 | |
| Doxribtimine SCHEMBL14596596 | 0.78 | TK1 (0.73) | LMNAPKMTK2TK1SMN1; SMN2 | |
| Doxribtimine SCHEMBL10382149 | 0.78 | TK1 (0.73) | LMNAPKMTK2TK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230193273-A1 | SIGNAL BOOST CASCADE ASSAY | VEDABIO, INC. | 2023-06-22 | — | — | US | claimed |
| WO-2023114090-A2 | SIGNAL BOOST CASCADE ASSAY | LABSIMPLY, INC. (US) | 2023-06-22 | — | — | WO | claimed |
| US-20240218364-A1 | SIGNAL BOOST CASCADE ASSAY | VEDABIO, INC. | 2024-07-04 | — | — | US | disclosed |
| EP-3707273-B1 | REAGENTS AND ADAPTERS FOR NUCLEIC ACID SEQUENCING AND METHODS FOR MAKING SUCH REAGENTS AND ADAPTERS | TWINSTRAND BIOSCIENCES INC (US) | 2024-04-10 | — | — | EP | disclosed |
| US-20240076716-A1 | REAGENTS AND ADAPTERS FOR NUCLEIC ACID SEQUENCING AND METHODS FOR MAKING SUCH REAGENTS AND ADAPTERS | TWINSTRAND BIOSCIENCES, INC. | 2024-03-07 | — | — | US | disclosed |
| US-20240035028-A1 | SIGNAL BOOST CASCADE ASSAY | VEDABIO, INC. | 2024-02-01 | — | — | US | disclosed |
| US-11884921-B2 | Signal boost cascade assay | VEDABIO, INC. (US) | 2024-01-30 | — | — | US | disclosed |
| US-20230279375-A1 | SIGNAL BOOST CASCADE ASSAY | VEDABIO, INC. | 2023-09-07 | — | — | US | disclosed |
| US-11739367-B2 | Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters | TWINSTRAND BIOSCIENCES, INC. (US) | 2023-08-29 | — | — | US | disclosed |
| US-20230235393-A1 | METHODS OF ENRICHING FOR TARGET NUCLEIC ACID MOLECULES AND USES THEREOF | QIAGEN SCIENCES, LLC | 2023-07-27 | — | — | US | disclosed |
| US-20230193273-A1 | SIGNAL BOOST CASCADE ASSAY | VEDABIO, INC. | 2023-06-22 | — | — | US | disclosed |
| WO-2021252867-A2 | METHODS OF ENRICHING FOR TARGET NUCELIC ACID MOLECULES AND USES THEREOF | QIAGEN SCIENCES, LLC (US) | 2021-12-16 | — | — | WO | disclosed |
| EP-3765063-A1 | METHODS AND REAGENTS FOR ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS | Twinstrand Biosciences, Inc. (US) | 2021-01-20 | — | — | EP | disclosed |
| US-20210010065-A1 | METHODS AND REAGENTS FOR ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS | TWINSTRAND BIOSCIENCES, INC. | 2021-01-14 | — | — | US | disclosed |
| US-20200362390-A1 | REAGENTS AND ADAPTERS FOR NUCLEIC ACID SEQUENCING AND METHODS FOR MAKING SUCH REAGENTS AND ADAPTERS | TWINSTRAND BIOSCIENCES, INC. | 2020-11-19 | — | — | US | disclosed |
| CN-111868255-A | Methods and reagents for enriching nucleic acid material for sequencing applications and other nucleic acid material interrogation | 特温斯特兰德生物科学有限公司 | 2020-10-30 | — | — | CN | disclosed |
| EP-3707273-A1 | REAGENTS AND ADAPTERS FOR NUCLEIC ACID SEQUENCING AND METHODS FOR MAKING SUCH REAGENTS AND ADAPTERS | Twinstrand Biosciences, Inc. (US) | 2020-09-16 | — | — | EP | disclosed |
| WO-2019178577-A1 | METHODS AND REAGENTS FOR ENRICHMENT OF NUCLEIC ACID MATERIAL FOR SEQUENCING APPLICATIONS AND OTHER NUCLEIC ACID MATERIAL INTERROGATIONS | TWINSTRAND BIOSCIENCES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| US-20090104614-A1 | QUANTITATIVE MOLECULAR PROBES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2009-04-23 | — | — | US | disclosed |
| WO-2007106900-A2 | QUANTITATIVE MOLECULAR PROBES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-09-20 | — | — | WO | disclosed |