Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.37 |
| ▸ | HAT1 | O14929 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PTGIR | P43119 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4271751 | 0.98 | PTGDR2 (0.45) | PTGDR2PPARGPPARAPTGDRHAT1 | |
| SCHEMBL4271773 | 0.85 | PTGDR2 (0.59) | PTGDR2PPARGPPARAPTGDR | |
| SCHEMBL4277978 | 0.83 | DAO (0.34) | PTGDR2PPARGPPARA | |
| SCHEMBL4267953 | 0.83 | PTGDR2 (0.59) | PTGDR2PPARGPPARAPTGDR | |
| SCHEMBL4268589 | 0.82 | PTGDR2 (0.58) | PTGDR2PPARGPPARAPTGDRPTGIR | |
| SCHEMBL4274009 | 0.80 | PTGDR2 (0.55) | PTGDR2PTGDRPTGIR | |
| SCHEMBL4274243 | 0.80 | PTGDR2 (0.42) | PTGDR2PPARGPPARAPTGDRHAT1 | |
| SCHEMBL4276035 | 0.79 | PTGDR2 (0.41) | PTGDR2PPARGPPARAPTGDRMTNR1A | |
| SCHEMBL4268719 | 0.78 | CYSLTR2 (0.43) | PTGDR2PTGDRPARP1 | |
| SCHEMBL4267885 | 0.77 | PTGDR2 (0.41) | PTGDR2PPARGPPARAPTGDRMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |