Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270867 | 0.96 | MTNR1A (0.42) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4278421 | 0.87 | CYP3A4 (0.45) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4272576 | 0.84 | MTNR1A (0.41) | MTNR1AMTNR1B | |
| SCHEMBL4270869 | 0.83 | CYP3A4 (0.44) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL5709046 | 0.81 | CHRM2 (0.54) | MTNR1AMTNR1BHDAC1HDAC6 | |
| SCHEMBL3193515 | 0.81 | KDM4E (0.41) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4268400 | 0.81 | CYP4F2 (0.50) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4282042 | 0.80 | MTNR1A (0.48) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL4268391 | 0.80 | CYP4F2 (0.54) | MTNR1AMTNR1BPPARAPPARGHDAC1 | |
| SCHEMBL3169528 | 0.80 | PPARA (0.64) | PPARAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |