Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 17/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286072 | 0.88 | AURKB (0.56) | AURKBHDAC1PIK3CA | |
| SCHEMBL4283698 | 0.83 | AURKB (0.60) | AURKBHDAC1PIK3CA | |
| SCHEMBL4283666 | 0.82 | AURKB (0.63) | AURKBHDAC1RPS6KB1 | |
| SCHEMBL4279183 | 0.82 | AURKB (0.61) | AURKBHDAC1PIK3CA | |
| SCHEMBL4280378 | 0.78 | AURKB (0.58) | AURKBHDAC1 | |
| SCHEMBL4284408 | 0.76 | SMN1; SMN2 (0.51) | AURKBHDAC1RPS6KB1 | |
| SCHEMBL4282342 | 0.75 | SMN1; SMN2 (0.53) | AURKBRPS6KB1 | |
| SCHEMBL4278966 | 0.74 | AURKB (0.59) | AURKBRPS6KB1 | |
| SCHEMBL8350666 | 0.70 | AURKB (0.78) | AURKBHDAC1 | |
| SCHEMBL6919054 | 0.70 | AURKB (0.77) | AURKBHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | claimed |
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ABBOTT LABORATORIES (US) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258907-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ROCK KINASES | ROCK1, ROCK2, RHOA | AURKB 276/4885HDAC1 825/4885AURKA 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.