Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.83 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL22497667 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL7058918 | 1.00 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL3068491 | 1.00 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL1318750 | 1.00 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL8327833 | 1.00 | TDP1 (0.83) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL131261 | 1.00 | — | — | |
| Propylene Glycol SCHEMBL28841734 | 0.96 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL28316305 | 0.96 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL28486346 | 0.96 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNATHRB | |
| Propylene Glycol SCHEMBL28309882 | 0.96 | TDP1 (0.77) | TDP1TSHRALDH1A1LMNATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009152392-A2 | MUSCARINIC AGONISTS FOR NEUROLOGICAL DISORDERS AND METHODS OF MAKING THE SAME | UNIVERSITY OF TOLEDO (US) | 2009-12-17 | — | — | WO | disclosed |