SCHEMBL4280281

SCHEMBL4280281

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nearest known ligand 0.42

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.34
PDE4A P27815 1/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
USP2 O75604 1/20 0.31
SLCO1B1 Q9Y6L6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4272338 1.00 TSHR (0.34) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4274462 1.00 TSHR (0.34) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4274454 1.00 TSHR (0.34) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4268324 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4282241 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL27946556 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4271266 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL4274437 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL2722434 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1
SCHEMBL111395 0.95 LMNA (0.35) TSHRPDE4AALDH1A1LMNAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090294362-A1 STATIONARY PHASE FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2009-12-03 US claimed
US-20180163056-A1 HYDROPHILIC CURABLE COMPOSITIONS MITSUI CHEMICALS, INC. (JP) 2018-06-14 US disclosed
US-20180036995-A1 HYDROPHILIC MONOLAYER FILM WITH OPTICAL FUNCTIONALITY AND STACK OF THE SAME MITSUI CHEMICALS, INC. (JP) 2018-02-08 US disclosed
EP-3270192-A1 HYDROPHILIC SINGLE-LAYER FILM HAVING OPTICAL FUNCTIONALITY, AND LAMINATE THEREOF Mitsui Chemicals, Inc. (JP) 2018-01-17 EP disclosed
EP-3081578-A1 COMPOSITION FOR HYDROPHILIC CURED PRODUCT Mitsui Chemicals, Inc. (JP) 2016-10-19 EP disclosed
US-20090294362-A1 STATIONARY PHASE FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2009-12-03 US disclosed